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Zheng H-L, Zhang H-Y, Zhu C-L, Li H-Y, Cui S, Jin J, et al

10.1038/s41416-021-01566-9 Br J Cancer

Zn-deficient wild-type and mutant human SOD1 have been implicated in the disease familial amyotrophic lateral sclerosis (FALS), also known as Lou Gehrigs disease which affects the nerve cells in the spinal cord and the brain.29, 30 Recently, Dayal and colleagues informed that deficiency of superoxide dismutase promoted cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.31 SOD enzyme deficiency is common

In addition to causing constant cellular injury, chronic inflammation creates a microenvironment very similar to that of cancers, which favors the establishment, infiltration, and growth of neoplasms (102)

3.3 Oxidative stress Oxidative stress generally refers to a state of imbalance between oxidation and antioxidant defense system (126)