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Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex

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In ALS, pathological intronic hexanucleotide GGGGCC expansions in the C9orf72 gene are thought to contribute to neurodegeneration by multiple mechanisms, including toxic cytoplasmic dipeptide repeat protein aggregates, toxic RNA gain-of-function, or loss of function due to haploinsufficiency [20, 21]

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