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Shi, X., de 637 Rezende, J

The authors have investigated three treatments to correct metabolic abnormalities which have demonstrated improvement in behavior and/or metabolism, namely the combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) to treat oxidative stress in an open-label study (James et al., 1A demonstrates where these agents are believed to act within four major interconnected metabolic pathways that are known to be disrupted in ASD

43 System Xc contains subunits SLC7A11 and SLC3A2, GPX4 and SLC7A11 inhibition cause accumulation of reactive oxygen species (ROS) and disruption of redox homeostasis

Luan, R.-L., Meng, X.-X., & Jiang, W

External factors include: Artificial light